M., Ekino, S., Nieuwenhuis, P., Koch, G., and De Boer, G. Early separation of B and T lymphocyte precursors in chicken embryo. Houssaint, E., Mansikka, A., and Vainio, O. Bu-1 antigen expression as a marker for B cell precursors in chicken embryos. Houssaint, E., Lassila, O., and Vainio, O. Ontogeny and tissue distribution of the chicken Bu-1 a antigen. A method for cDNA cloning in COS cells irrespective of subcellular site of expression. A new method for predicting signal sequence cleavage sites Nucleic Acids Res 14: 4683–4690, 1986 Genetic interaction between non-MHC T- and B-cell alloantigens in response to Rous sarcomas in chickens. Two loci determining surface antigens of B or T lymphocytes in the chicken. G., Brand, A., Donnelly, N., and Stone, H. Influence of genotypes at a non-MHC B lymphocytes alloantigen locus (Bu-1) on expression of Ia (B-L) antigen on chicken bursal lymphocytes. cDNA sequence of cattle MHC class I genes transcribed in serologically defined haplotypes A18 and A31. Preliminary linkage map of the chicken ( Gallus domesticus) genome based on microsatellite markers: 77 new markers mapped. A preliminary linkage map of the chicken genome. Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development. The Leukocyte Antigen Facts Book, Academic Press, London, 1993īenatar, T., Tkalec, L., and Ratcliffe, M. A restriction fragment length polymorphism linked to the CHB6 gene has been used to determine its location on the linkage map of the chicken genome, which will allow the definitive evaluation of reported associations with disease resistance.īarclay, A. The sequences of the different alleles of this gene revealed a higher level of polymorphism than expected.
Its presence in chickens may be related to differences in the properties of B-cell development between chickens and mammalian species. It has no recognizable similarity to known mammalian molecules and thus represents a unique B-cell marker. The results show that chB6 is a typical type I transmembrane protein, highly glycosylated in the extracellular region and carrying a large intracellular region. We isolated a chB6 cDNA by expression cloning and sequenced two further alleles following polymerase chain reaction amplification. It has long been used as an allotypic marker in important studies of B-cell development, though its function is unknown. The chB6 molecule is expressed on chicken B cells throughout most of their development, as well as on some non-lymphoid cells.
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